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Zur Anwendung kommt in der klinischen Praxis hufig Pirenzepin/Gastrozepin 25-50 mg/d (Anticholinergikum mit relativ selektivem Antagonismus an M1- und M4-Rezeptoren) [5], das wirksam ist, aber die Gefahr der Zunahme der anticholinergen Nebenwirkungen von Clozapin (bis zum Ileus, siehe unten) erhht