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Potential Therapeutic Benefits of S-Adenosylmethionine SAM-e is claimed to be helpful for the following conditions: Depression Parkinson's disease Osteoarthritis symptoms Liver disease Intrahepatic cholestasis (of pregnancy especially) Fibromyalgia AIDS-related myelopathy There has be also limited research that has referenced for SAM-e's role in the following conditions: Attention deficit hyperactivity disorder (ADHD) Premenstrual syndrome (PMS) Premenstrual dysphoric disorder (PMDD) Chronic fatigue syndrome (CFS) Heart disease Defective intellectual performance Multiple sclerosis Dementia Alzheimers disease Tendonitis Bursitis Spinal cord injury Seizure Migraine headache Chronic low back pain Lead poisoning Aging Methylation Index Since SAM is an intrinsically unstable molecule, the determination of its concentration in various biological fluids and tissues has always been a challenging task

Results from experiments with murine melanoma cells and human ovarian cancer cells suggest that PD-L1-overexpressing cells are more responsive to autophagy inhibitors than cells with weak PD-L1 expression

Br J Pharmacol 140: 1399413, 2003