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Arribas-Lpez, E

Front Oncol (2022) 12:967207

This kind of damage can lead to an inability to adapt to new experiences and contribute to feeling depressed

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The variability in trial durations, ranging from 3 to 12 weeks across the included studies, and differences in the number of titration steps for each drug may further influence the reported incidence of gastrointestinal adverse events, particularly for agents like tirzepatide, where nausea risk escalates with higher doses (e.g., OR = 4.36, 95% CI: 3.425.61 at 10 mg) (Liu et al., 2025)

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