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Specifically, SIRT4 interacts with U2 small nuclear RNA auxiliary factor 2 (U2AF2) at the K413 site under TGF- 1 stimulation or renal injury to deacetylate U2AF2, promoting cellular communication network 2 (CCN2, a marker of fibrosis activity) expression through alternative pre-mRNA splicing, ultimately contributing to the progression of kidney fibrosis

[DOI] [PubMed] [Google Scholar] 138.Kuceki G., Coppinger A.J., Ragi S.D., Johnson L.S., Goren A., Kalil L.L., Cirino P., Wambier C.G

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