MDM2 Polyclonal Antibody, 100ul[BT-AP05301] Electrophoresis & Labeling The encoded protein is a

The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils

including neurotransmission and antimicrobial and antitumoral activities

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|subunit:Component of the toroidal 9-1-1 (RAD9-RAD1-HUS1) complex| composed of RAD9A| RAD1 and HUS1

subcellular location:Upon EGF stimulation

MDM2 Polyclonal Antibody, 100ul[BT-AP05301] Electrophoresis & Labeling The encoded protein is aMDM2 encodes a nuclear localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. MDM2 is itself transcriptionally regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many