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Methods We used a combination of glucagon secretion measurements in mouse and human islets (including islets from donors with type 2 diabetes), total internal reflection fluorescence microscopy imaging of secretory granule dynamics, recordings of cytoplasmic Ca 2+ and measurements of protein kinase A activity, immunocytochemistry, in vivo physiology and GTP-binding protein dissociation studies to explore how GLP-1 exerts its inhibitory effect on glucagon secretion and the role of the metabolite GLP-1(936)

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Editors FeehallyJ.FloegeJ.JohnsonR

Racial distribution in the GLP-1 RA group was 62.9% White, 19.4% Black or African American, and 4.5% Asian, comparable to 63.3%, 19.8%, and 4.1% respectively in the control group