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Curcumin in vitro neuroprotective effects are mediated by p62/keap-1/Nrf2 and PI3K/AKT signaling pathway and autophagy inhibition

Lee SH, Ko HM, Jee W, Kim H, Chung WS, Jang HJ

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However, the long-term administration of the GnRH analog reduces ovarian hormone production and secretion, which downregulates and desensitizes the GnRH receptor in pituitary gonadotropic cells 116

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