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This metabolic rewiring suggests that the Warburg effect and ferroptosis evasion may be mechanistically linked, representing complementary adaptive strategies that collectively support malignant transformation and tumor progression

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In a type 1 diabetic Akita mouse model, which was used as a nonobese insulin-dependent model of spontaneous type 1 diabetes, empagliflozin treatment attenuated diabetes-induced rise in renal expression of markers of kidney growth by reducing the cyclin-dependent kinase inhibitors p27 and p21, which were over-expressed in early diabetic kidneys (152)