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intranasal doses of approximately 120 mcg/kg used in animal research Timing: Evening administration, typically 30 to 60 minutes before intended sleep Onset: Sleep pressure reported within approximately 130 minutes of administration in human studies Duration: Effects on sleep architecture observed with both single doses and multi-day protocols Regarding cycling, the evidence is mixed

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One human study found that exercise can raise circulating levels , which supports its biological relevance but doesnt show that injections make health outcomes better

In addition, effective treatment of symptom flares may require a pain treatment protocol with some flexibility to manage flare-related breakthrough pain

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