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The spread of obesity in a large social network over 32 years

Some studies suggest potential roles in angiogenesis, collagen-related repair processes, inflammatory signaling, and protection of different tissue types

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Interestingly, a selective upregulation of the bitter TR TR2R138 was shown in the colon of mice fed a high fat diet (31), and T2R38, a human receptor activated by the same ligand, phenylthiocarbaminde, has been demonstrated not only to be expressed in EEC of the colonic mucosa but also to be induced in overweight/obese subjects (32)

pretty straightforward

Stop your medication and seek emergency care immediately if you experience severe abdominal pain that doesnt go away, especially if it spreads to your back