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In obese nude mice, tumors derived from MDAMB231 CRISPR/Cas9mediated EIF3H knockout (EIF3H KO) cells also exhibited significantly slower growth and smaller tumor sizes compared to the control group (Figure S9A,B, Supporting Information)

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These findings indicate a great potential of the dual-targeting strategy ( General Features of MCT9 (SLC16A9) and Implications in Cancer MCT9 is a plasma membrane transporter belonging to the monocarboxylic acid transporter family SLC16 that counts 14 members