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Keap1 is a cysteine-rich protein that can be oxidized by ROS and results in conformational change, which in turn liberates NRF2

PMID 8586147

Enhancing Nrf2 activity in renal tubules decreases oxidative stress and prevents kidney disease progression [66]

Scientists say the potential is possible thanks to one major difference: retatrutides unique formulation that makes it stand out among other weight-loss drugs, including Eli Lillys own Zepbound