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Nitric oxide (NO) and carbon monoxide negatively modulate the HPA axis by reducing CRH release, at least in vitro (106,107)

3 Orthodontics The action of predefined orthodontic forces causes mechanical stimuli that result in two simultaneous processes that move the teeth: bone resorption at the pressure site by osteoclastic activity and bone creation at the stress site by osteoblastic activity

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The mechanism likely involves coordinated mTOR activation and nitric oxide upregulationtwo pathways that prime the body's repair machinery