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However, contrasting data from other studies showed that the addition of PDE4i rolipram to standard TB treatment accelerated mortality, increased the bacterial burden, and did not reduce the time to bacterial clearance in the lungs of a mouse model of TB [34], raising concerns about the general applicability of PDE-Is

Studies on AD related mitochondrial dysfunction that exhibits sex specific characteristics could lead to developing personalized therapeutic strategies for this devastating disease

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Nishida S, Yoshida LS, Shimoyama T, Nunoi H, Kobayashi T, et al

doi: 10.1016/j.bbrc.2007.08.079