glp-1 receptor agonists and cancer risk in adults with obesity Among #obesity, use of #GLP-1 was associated with reduced of developing several #cancers, including #endometrial, #ovarian, meningioma, compared with those not The effect of GLP-1R agonists

More promising results, however, were announced the same month by Eli Lilly for its new once-daily GLP-1 pill which showed promise for weight management and for the treatment of type-2 diabetes

Abbreviations AMPK: AMP-activated protein kinase DPP-4: Dipeptidyl peptidase-4 GIP: Glucose-dependent insulinotropic polypeptide GLP-1: Glucagon-like peptide 1 PPAR: Peroxisome proliferator-activated receptor References Nathan DM, Buse JB, Davidson MB et al (2009) Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes

iScience 24 , 116 (2021)

These include muscle weakness (difficulty climbing stairs, rising from a chair, or lifting objects), persistent muscle pain or tenderness, visible muscle swelling or changes in muscle appearance, or dark-colored urine, which may indicate rhabdomyolysisa rare but serious condition involving muscle breakdown

However, GLP-1RAs markedly reduced postprandial increases in triglycerides, apolipoprotein (Apo)B48 (major structural protein of chylomicrons), and ApoC-III (key regulator of triglyceride-rich lipoprotein metabolism), independently of gastric emptying [38,39,40]

and improving recognition (116)