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349,350 This change suggests that liraglutide not only inhibits inflammation and cartilage degradation but may also promote the synthesis and accumulation of cartilage matrix, thereby helping to protect and repair joint cartilage

It just means that in clinical trials, midlife women are grouped into broader categories, making it hard to draw firm conclusions about how well GLP-1s work for this unique stage of life as compared to other populations

Add fiber-rich foods or supplements gradually, and drink plenty of water to support digestion

In addition, it is important to notice that the ubiquitous DPP-IV protease targets not only GLP-1 but also oxyntomodulin, GIP and PYY among other proteins (235)

The ultimate classification of GLP-1 agonists as game-changing or overhyped will depend on societys ability to address the implementation challenges that currently limit their transformative potential