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We dont fully know the safety of TB-500 because we dont have long-term studies in humans

Hsieh and colleagues (J Mol Med, 2017, PMID 27847966) reported upregulation and internalisation of VEGFR2 in human umbilical vein endothelial cells

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This agent has been studied in a 14-week trial and showed improvement in gouty symptoms.15 This agent may have a future role in preventing gout attacks when patients are started on a uric acid lowering agent but can take the usual prophylactic agents against the attacks that often are an early result of this therapy (for example, they can't use colchicine)