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Transdermal Drug Delivery Systems (TDDS) Transdermal drug delivery systems (TDDS) are non-invasive methods of drug delivery through the skin

The root of the tongue connects it to the jaw and to the hyoid bone, while the body stores on its surface four distinct lingual papillae, each with a unique anatomical and functional characteristic and an individual relationship with taste perception ( Figure 1 ) It is also important to highlight the complex neuronal architecture of the tongue, as we should consider three different innervation types: 1) Autonomic innervation: generates the salivatory stimuli and regulation of local blood flow, that plays an important role in food pleasure and avoidance ( C, A-, and A- fibers (31)

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