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The established Observed Safe Level (OSL) for chronic, long-term supplementation is generally recognized as 2,000 mg per day, though higher doses have been used safely in monitored trials

7) For statistical analyses involving multiple comparisons, care should be taken in determining which p-values are most significant

In another study, six weeks of 1000 mg NR supplementation per day for CKD patients improved mitochondrial metabolism, yet no effects were observed in the physical endurance of skeletal muscle 315

We also third Party Lab Test our coffee so it is free of mycotoxins, mold, fungus, heavy metals and pesticides