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Mechanistically, farnesoid X receptor (FXR), a nuclear receptor that acts as a sensor of intracellular bile acid levels, plays a critical role in TMAO-mediated bile acid disruption, since liver FMO3 expression is upregulated by dietary bile acids through an FXR-mediated pathway [19]

Whether the right answer turns out to be a dose pause, a slower titration, supportive medication, a switch between Wegovy and Zepbound, or a different approach, we want to be in the conversation when that decision is made

How would you describe your current approach to weight management

J Transl Med 14: 213, 2016