FBLN1 Polyclonal Antibody, 100ul Subcellular Fractions Mutations in this gene are

Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes

and this localization is required for mitosis to proceed normally

protein tyrosine kinase 2 beta has been shown to bind CRK-associated substrate

INCENP (inner centromere protein) and survivin

This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway

FBLN1 Polyclonal Antibody, 100ul Subcellular Fractions Mutations in this gene areFibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants.