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The following are its specific uses in the field of skin care and beauty: Potential uses in special beauty care needs Stretch marks are a common skin problem for pregnant women during pregnancy, mainly caused by the rapid expansion of abdominal skin in a short period of time, leading to the rupture of elastic fibers and collagen in the skin

Modulated genes included those involved in GABA transport, serotonin receptor expression, and immune signaling

Competing interests The authors have no relevant financial or non-financial interests to disclose

Here are some key research findings on GHK-Cu: Collagen production: In a placebo-controlled study, GHK-Cu improved collagen production in 70% of participants, outperforming both vitamin C cream and retinoic acid Skin quality: A 12-week facial cream trial on 71 women with photoaging showed improved skin laxity, clarity, firmness, and increased skin density and thickness Wrinkle reduction: A 2016 study in the Journal of Aging Science found GHK-Cu in nano-carrier formulation reduced wrinkle volume by 31.6% compared to a commercial peptide product Broader effects: Promotes angiogenesis, supports nerve outgrowth, and demonstrates antioxidant and anti-inflammatory activity in cell culture and animal models GHK-Cu can be administered by subcutaneous injection or topical application, with injectable forms offering higher bioavailability

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Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ