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Traditional methods like bariatric surgery, dietary supplements, and off-label prescribing of anti-obesity medications had their limitations

In the trials of CONTRAVE, 4,536 patients from four different institutions were tested

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doi: 10.1177/1479164111404257 [DOI] [PubMed] [Google Scholar] 7

VEGFA secreted from cancer cells binds to VEGFR2 on endothelial cells, phosphorylates and activates VEGFR2, which then phosphorylates downstream extracellular signal-regulated kinase (ERK1/2) thus promoting angiogenesis (Ferracini et al., in vivo tumor angiogenesis by inhibiting VEGFA production through HGF/c-Met axis in HCC cells