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Ribaldone DG, Fagoonee S, Astegiano M, De Angelis C, Smedile A, Caviglia GP et al

Those with low baseline GLP-1 secretion, insulin resistance, or genetic variants associated with blunted pathway activation may plateau despite sustained lifestyle effort

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In a 2022 study, Santoro found that after 16 weeks of exercise, meal control, and the over-the-counter drug orlistat (Alli), we did not see an improvement in pregnancy rate. In a similar 2016 study in the Netherlands, the weight-loss intervention resulted in a slight decrease in the pregnancy rate

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