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The rise of artificial intelligence has led to the increasing use of data mining techniques, with complex network analysis based on graph theory offering a promising approach for clinical application (9,10)

A primary care practitioner can often manage gout without the patient having a consultation with a rheumatologist, but a consultation should be considered if the diagnosis is unclear, there is uncertainty as to whether or not to start uric acid-lowering medication, attacks continue to occur despite treatment, or possible medication side effects are making treatment difficult

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This is evidenced by changes in microglial morphology and transcriptional profiles, which are influenced by molecular signals encountered during their surveillance (Davalos et al., 2005