PYR-41 - Ubiquitin-activating Enzyme E1 Inhibitor. CAS# 418805-02-4 60290 and amyotrophic lateral sclerosis

and amyotrophic lateral sclerosis

53(24):8468-84

Smiles: CCN1C=C(C2SC(=CC=2C1=O)C(=N)NC1CCS(=O)(=O)CC1)C1=CC(=CC=C1)C(F)(F)F

Endurobol was entered into clinical development as a drug candidate for metabolic diseases and cardiovascular diseases

Becerra CR

PYR-41 - Ubiquitin-activating Enzyme E1 Inhibitor. CAS# 418805-02-4 60290 and amyotrophic lateral sclerosisPYR 41, CAS No. 418805 02 4, is a ubiquitin activating enzyme inhibitor (UBE1 inhibitor). PYR 41 blocks ubiquitination reactions but paradoxically leads to the accumulation of high MW ubiquitinated proteins. PYR 41 also mediated cross linking of specific protein kinases (Bcr Abl, Jak2) to inhibit their signaling activity. PYR 41 has demonstrated anti tumor activity in animal studies, partially selective protein cross linking may represent an alternate