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The timing of administration matters: evening dosing (30-60 minutes before sleep) capitalizes on the natural nocturnal GH pulse, potentially producing a synergistic effect with endogenous GH secretion

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Protection against DIO by SANA was due to decreased fat accumulation in all adipose depots analysed (Fig

Pharmacologically, tirzepatide slows gastric emptying, which prolongs the sensation of fullness after eating, though this effect tends to diminish somewhat over time with continued treatment

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