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Direct regulation of cancer cell proliferation, apoptosis, migration and invasion GLP-1RAs exert their biological effects primarily by binding specifically to and activating the GLP-1 receptor (GLP-1R) [17, 38, 55]

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It is important to note that serum magnesium represents only a small fraction of total body magnesium, so normal blood levels do not always exclude deficiency

Nausea, vomiting, and diarrhea may affect fluid balance and lead to dehydration

Bruises that expand rapidly over hours, bruises larger than 3 inches in diameter, or bruises accompanied by increasing pain, warmth, or redness may indicate infection or hematoma formation

It is important to distinguish between urinary changes related to GLP-1 therapy and those caused by other diabetes medications, particularly SGLT2 inhibitors (such as dapagliflozin, empagliflozin), which do directly increase urination as their primary mechanism of action