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MTX and Glucocorticoids An experimental study demonstrated that an oral pretreatment with dexamethasone reduces up to 53% of the biliary clearance of MTX, inducing a hepatocellular impairment [65]

Inflammopharmacology 31:25992614 Kawaguchi S, Fujiwara S-i, Murahashi R, Nakashima H, Matsuoka S, Ikeda T, Toda Y, Ito S, Ban T, Nagayama T (2021) Risk factors for high-dose methotrexate-induced nephrotoxicity