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As one nephrologist at ASN 2025 put it: These drugs seem to ease the metabolic and volume burden that quietly erodes kidney function . Although the data is promising, GLP-1s may not yet be considered as a renal monotherapy

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The hallmark therapeutic activity of KD in ASD involves the production of significantly higher levels of ATP through bio-energetic pathways involving oxidation of NADH, dampening of inflammatory pathways, maintaining the integrity of the mitochondrial membrane, de novo biogenesis of mitochondria, reduction in the activity of pro-apoptosis factors, and reduced production of ROS

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However, the underlying pathophysiology remains unclear

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