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AES Polyclonal Antibody, 50ul Buffer Solutions Defects in ATG16L1 are a

SKU: 40639133003

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AES Polyclonal Antibody, 50ul Buffer Solutions Defects in ATG16L1 are aThe protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho a protein involved in neurogenesis during embryonic development. The encoded protein which belongs to the groucho TLE family of proteins can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms

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Description

Defects in ATG16L1 are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10)

The chondroitin sulfate proteoglycan NG2 is a type I membrane protein expressed by subpopulations of glia including oligodendroglial precursor cells and a variety of tumor cells

including heparan sulfate

Some haplotypes of this gene show a positive association with schizophrenia

Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity

AES Polyclonal Antibody, 50ul Buffer Solutions Defects in ATG16L1 are aThe protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho a protein involved in neurogenesis during embryonic development. The encoded protein which belongs to the groucho TLE family of proteins can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms

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