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Taken together, our patient platform defines the mechanisms of GLP-1R action in neurons and astrocytes, identifies the population likely to benefit from GLP-1R agonism, and highlights the utility of GLP-1R agonism as a disease modifying strategy in synucleinopathies

Aligning with the observed lower risk for incident MACEs, researchers found a smaller composite MACE incidence rate with tirzepatide vs

A 2024 meta-analysis of 27 randomised controlled trials involving approximately 200,000 participants found that GLP-1 receptor agonists were associated with a 24% reduced risk of seizures and epilepsy compared to placebo