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doi: 10.1523/JNEUROSCI.6200-10.2011

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This pattern helps explain why people who use alcohol as a sleep aid often find themselves caught in a difficult cycle: the disrupted sleep leads to tiredness and sleep inertia the next day, potentially encouraging them to drink again the following night to fall asleep, creating an unhealthy pattern that can worsen over time

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Some usage-limiting properties of the designed peptides, including low selectivity and tumor cell uptake, poor tumor permeability and passing through the BBB in glioma cancer, and low plasma stability, can be improved by several techniques, such as intracellular delivery via the intracellular pathway, ligand-mediated tumor targeting, and nanoparticle-based drug delivery systems

Adequate function of white blood cells is essential in mounting an effective immune response