Alvespimycin Hydrochloride Catalog No.:M10918-2 but promotes Akt/PKB down-regulation and

but promotes Akt/PKB down-regulation and GSK3 activation

pharmaceutically acceptable salts thereof and compositions containing said inhibitors for prophylaxis and treatment of viral diseases

Toxins (Basel)

TAS-116 (0-5 μM

Its name is derived from the word "hesperidium"

Alvespimycin Hydrochloride Catalog No.:M10918-2 but promotes Akt/PKB down-regulation andAlvespimycin is an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. Check for active clinical trials or