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15 GLP-1RAs also improve -cell proliferation and inhibit -cell apoptosis to promote cellular survival by preventing oxidative stress and lipotoxicity

Although the FAERS database aids in detecting rare adverse events via spontaneous reporting, its propensity to overestimate unexpected adverse events linked to new therapies makes it inappropriate for comparative analysis of adverse event frequencies among pharmaceuticals

GLP-1 receptors are present in the brain, cerebral blood vessels, pancreas, heart, gastrointestinal tract, adipose tissue, kidney, and muscles, and consequently affect a variety of systems and processes [38,39,40]

Smaller numbers of genes with complete intact open reading frames were found for the putative Gcgr , Glp1r , and Glp2r genes ( Table 1 , Supplementary Tables 3 5 , and Supplementary Files 2 4 ), which likely reflects the larger sizes of these genes (1350-1600 coding bases and 13 coding exons) compared to the Gcg gene (540 coding bases and 5 coding exons)