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This double-blind, placebo-controlled study randomized adults with a BMI 30 or 27 plus at least one obesity-related comorbidity (excluding diabetes) who had achieved 5% weight loss after 12 weeks of lifestyle modification to receive tirzepatide or placebo weekly for 72 weeks

The reported distribution of causes of death for this cohort included: CVD (36%) Cancer (32%) Natural Causes (25%) Other/suicide/accidents (6%) 4 While the authors didnt investigate the association between cause of death and POP chemicals, there is substantial human and animal evidence linking POP exposure to mortality from both cardiovascular disease (CVD) and cancer, which were the two most common causes of death in this study.29,30 Moreover, the study population was derived from Finland, a country with several known POP toxicity risk hotspots