Siah-2 Polyclonal Antibody, 100ul Yeast Expression It is also found to

It is also found to be expressed in lipogenic breast cancers| which suggests a role in controlling tumor lipid metabolism

Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis

as well as in the control of beta-catenin signaling

through binding to its C-terminal region

Amplification and overexpression of this gene have been observed in several types of human carcinomas

Siah-2 Polyclonal Antibody, 100ul Yeast Expression It is also found toSIAH2 encodes E3 ubiquitin protein ligase SIAH2 that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia.