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Belonging to the Relaxin-peptide superfamily, INSL-5 has recently been identified as anorexigenic hormone

[27] [29] Attempts to bypass that issue by infusing patients in clinical tests with very high doses of GLP-1in order to overcome its rapid metabolism in the bloodstreamhad produced extremely severe nausea, followed by immediate vomiting

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Advantages over single agonist: GIP appears to work synergistically with GLP-1 rather than additively, explaining the 6 percentage point improvement over Semaglutide