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documented efficacy in improving desire scores and reducing distress associated with low libido Low libido in postmenopausal women: off-label use investigated where hormonal changes have reduced sexual desire and standard hormone therapy has not fully addressed the desire component Low sexual desire and erectile dysfunction in men: off-label use investigated for men where low libido (desire component) coexists with erectile difficulty, either as monotherapy or alongside PDE5 inhibitors Sexual dysfunction with psychological or stress-related components: PT-141's central mechanism may be particularly relevant where desire is suppressed by psychological factors rather than purely vascular ones Patients who have not responded adequately to PDE5 inhibitors alone: PT-141 adds the central desire component that PDE5i do not address PT-141 is the only FDA-approved medication that treats low sexual desire through a central neural mechanism rather than a peripheral vascular one

(4) Alba M, Fintini D, Sagazio A, Lawrence B, Castaigne JP, Frohman LA, Salvatori R

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Tesamorelin may be considered for adults who: Struggle with a growing waistline despite steady effort

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Yaffe SJ, Avery ME, Gold AP, Kenny FM, Riley HD Jr, Schafer IA, et al