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As NAD+ supplementation research has expanded dramatically, the discovery that NNMT depletes NAD+ precursors specifically in metabolically dysfunctional fat tissue provides a targeted intervention point

PMID: 30074168

Adipose vs Other NNMT Research Contexts While adipose is the most-developed NNMT-inhibition research application, NNMT biology has been studied in other contexts too: 5-Amino-1MQ as a tool compound has utility across these contexts, but adipose research is currently the deepest and most-established application area

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Healthcare providers use guidelines to decide the right dose and how often to give it